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Principles and Practice of Neuro-Oncology


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Principles and Practice of Neuro-Oncology
The field of neuro-oncology has experienced rapid growth in the last decade, characterized by robust advances in epidemiology, molecular biology, imaging, histopathologic harmonization, neurosurgical techniques, quality of life and cognitive functions, and therapeutic changes in terms of combined modality treatments, advanced radiation techniques, the advent of new drugs, especially targeted agents, and the tantalizing early promise of personalized therapeutic approaches. As dramatic as these changes are, we are merely at the cusp of an exponential explosion in knowledge in the field of neuro-oncology. This dramatic advance in our knowledge-base makes it almost impossible for any one person to keep pace, thereby underscoring the need for a comprehensive text incorporating these various elements in one common reference source.
This book is designed specifically with a multi-disciplinary focus, as neuro-oncology today is a superb example of the intersection of various specialties for the optimum management of a patient with a brain tumor.
The text is specifically designed for step-wise progression in the data and knowledge regarding various types of brain tumors, starting with epidemiology, progressing through with an understanding of etiologic factors, histopathogenesis, molecular biology, clinical presentation, imaging characteristics, and a comprehensive set of chapters on therapeutic options. Pulling together such a broad range of topics required expertise from various specialties, and this resulted in the creation of a truly multidisciplinary text.

CONTENTS:

Part I: EPIDEMIOLOGY
1. Epidemiology and Etiology of Glioma: An Overview
2. Descriptive Epidemiology of Glioma
3. Familial Factors and Inherited Susceptibility to Glioma
4. Chemical Exposures Mediated Through Occupation, Environment and Lifestyle, and Brain Tumor Risk
5. Exposure to Ionizing Radiation and Glioma Risk
6. Radiofrequency Fields and Glioma Risk
7. Allergies and Glioma Risk
8. Glioma Survival and Prognosis
9. Epidemiology of Childhood Brain Tumors
10. Meningioma Genetics

Part II: MOLECULAR BIOLOGY
11. Molecular Neuro-Oncology: Why is it Essential?
12. Brain Tumor Initiating Cells: History, New Advances, Therapeutic Promises, and Pitfalls
13. Molecular Pathogenesis of Glioma: Overview and Therapeutic Implications
14. Molecular Heterogeneity and Tumor Microenvironment
15. Molecular Regulators of Glioma Invasion
16. Molecular Basis of Glioma Neovascularization and Its Therapeutic Applications
17. Mouse Models of Central Nervous System Tumors
18. Pathology and Genetics of Meningiomas
19. Histopathology and Molecular Pathogenesis of Schwannomas
20. Histopathology and Molecular Pathogenesis of Pituitary Adenomas
21. Histopathology and Molecular Pathogenesis of Neurofibromas and Malignant Peripheral Nerve Sheath Tumors
22. The ‘Cell of Origin’ for Common Pediatric Brain Tumors
23. Histopathological Features of Common Pediatric Brain Tumors
24. Molecular Genetics of Medulloblastoma and High-Grade Astrocytomas in Children
25. Molecular Pathogenesis of Neuroblastomas
26. Pediatric Brain Tumor Syndromes and Murine Models
27. Predisposition Syndromes: Neurofibromatosis 1, Neurofibromatosis 2, and Tuberous Sclerosis Complex

Part III: CLINICAL PRESENTATION AND SUPPORTIVE CARE
28. Presentation and Clinical Features of Supratentorial Gliomas in Adults
29. Presentation and Clinical Features of Brain Metastases
30. Presentation and Clinical Features of Medulloblastoma
31. Presentation and Clinical Features of Pediatric Gliomas
32. Presentation and Clinical Features of Brainstem Tumors
33. Presentation and Clinical Features of Tumors of the Skull Base and Cranial Nerves
34. Presentation and Clinical Features of Tumors of the Pituitary and Sellar Region
35. Presentation and Clinical Features of Spinal Cord Tumors
36. Supportive Care in Neuro-Oncology
37. Ethical Issues in Neuro-Oncology
38. Role of Support Groups and Caregivers in Neuro-Oncology
39. Neurocognitive Function and Quality of Life
40. Neuropsychological Sequelae of Adult Brain Tumors
41. Neuropsychological Sequelae Associated with Pediatric Brain Tumors: What We’ve Learned Over the Past 40 Years
42. Rehabilitation of Central Nervous System Tumors
43. Palliative Care in Neuro-Oncology
44. Imaging of Brain Tumors

Part IV: NEUROANATOMY AND NEUROSURGERY
45. Functional Neuroanatomy
46. Skull Base Anatomy, Pathology, and Approaches: An Overview
47. Surgical Navigation
48. Stereotactic Brain Biopsy
49. Intraoperative Anatomical Imaging
50. Intraoperative Molecular Imaging
51. Intraoperative Functional Mapping
52. Endoscopy
53. Transsphenoidal
54. Spinal Neoplasms
55. Spinal Cord Tumors
56. Low-Grade Gliomas
57. Pineal Gland Tumors
58. Intraventricular Tumors
59. Insular Tumors
60. Pediatric Tumor Surgery
61. Brachial Plexus Tumors

Part V: MEDICAL ONCOLOGY
62. General Principles
63. Medical Management of Supratentorial Gliomas in Adults
64. Medical Management for Pediatric Gliomas
65. Medical Management of Primitive Neuroectodermal Tumors
66. Intracranial Meningiomas
67. Medical Management for Brainstem Tumors
68. Chemotherapy for Tumors of the Skull Base and Cranial Nerves
69. Tumors of the Pituitary and Sellar Region
70. Medical Treatment of Spinal Cord Tumors
71. Brain Metastases and Leptomeningeal Disease
72. Primary Central Nervous System Lymphoma
73. Medical Treatment of Primary Central Nervous System Germ Cell Tumors
74. Medical Management for Choroid Plexus Tumors
75. General Principles of Targeted Therapies
76. General Principles of Angiogenesis
77. Inhibitors of Signal Transduction Pathways in Malignant Glioma Therapy
78. Biologics
79. Other Therapies
80. Alternative Therapies

Part VI: RADIATION THERAPY
81. Introduction to Radiation Therapy
82. Radiation for Glioblastoma
83. Anaplastic Glioma
84. Low-Grade Glioma Radiation Therapy
85. Ganglioglioma
86. Optic Pathway Glioma
87. The Current Role for Radiation Therapy in Pediatric Grade II-IV (Non-JPA) Gliomas
88. Medulloblastoma and Primitive Neuroectodermal Tumors
89. Adult and Pediatric Pilocytic Astrocytoma
90. Ependymoma (Intracranial)
91. Vestibular Schwannoma
92. Hemangioblastoma and Hemangiopericytoma
93. Radiation Therapy for Intracranial Meningiomas
94. Adult and Pediatric Brainstem Glioma
95. Tumors of the Base of Skull
96. Pituitary Tumors and Craniopharyngioma
97. Primary Central Nervous System Germ Cell Tumors, Pineal Tumors, and Other Tumors of the Pineal and Sellar Regions
98. Primary Central Nervous System Lymphoma
99. Neurocytoma
100. Radiation Therapy of Primary Spinal Cord Tumors
101. Metastatic Disease
Index

Title: Principles and Practice of Neuro-Oncology
Authors: Minesh P. Mehta, Susan M. Chang, Herbert B. Newton, Abhijit Guha, Michael A. Vogelbaum
Language: English

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