Handbook of Therapeutic Antibodies - Rincón Médico
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Handbook of Therapeutic Antibodies


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Handbook of Therapeutic Antibodies

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content.
Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index.

Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

CONTENTS:

Volume I: Def ining the Right Antibody Composition
1. Therapeutic Antibodies – from Past to Future
Part I: Selecting and Shaping the Antibody Molecule
2. Selection Strategies for Monoclonal Antibodies
3. Antibody Phage Display
4. Transgenic Animals Derived by DNA Microinjection
5. Humanization Strategies
6. Antibody Aff
7. Fc Engineeringinity
8. Glycosylation of Antibody Molecules
9. Bioinformatics Tools for Analysis of Antibodies
10. How to Use IMGT® for Therapeutic Antibody Engineering
Part II: Modified Antibodies
11. Bispecific Antibodies
12. Single-Domain Antibodies: An Overview
13. Antibody–Drug Conjugates: New Frontier in Cancer Therapeutics
14. Antibody-Targeted Drugs: From Chemical Immunoconjugates to Recombinant Fusion Proteins
Part III: Emerging Technologies
15. Emerging Technologies for Antibody Selection
16. Anti-Idiotypic Antibodies
17. Non-Antibody Scaffolds as Alternative Therapeutic Agents
18 Antibody-Directed Enzyme Prodrug Therapy (ADEPT)
19. Engineered Antibody Domains as Candidate Therapeutics
20. Chimeric Antigen Receptors –‘‘CARs’’
21. Emerging Alternative Production Systems

Volume II: Clinical Development of Antibodies
Part IV: The Way into the Clinic
22. Process Development and Manufacturing of Therapeutic
23. The Immunogenicity of Therapeutic Antibodies
24. Biosimilar Monoclonal Antibodies
25. Patent Issues Relating to Therapeutic Antibodies
Part V: Therapeutic Antibody Pipeline
26. Monoclonal Antibody Cancer Treatments in Phase III Clinical Trials
27. Antibodies in Cancer Treatment: Early Clinical Development
28. Targeting Angiogenesis by Therapeutic Antibodies
29. Antibodies in Phase III Studies for Immunological Disorders
30. Monoclonal Antibodies in Phase 1 and 2 Studies for Immunological Disorders
31. MAbs Targeting Soluble Mediators in Phase 1 and 2 Clinical Studies Immunological Disorders
32. T Cell Inhibitors in Phase 1 and 2 Clinical Studies for Immunological Disorders
33. B-Cell Inhibitors in Phase 1 and 2 Clinical Studies for Immunological Disorders
34. Inhibitors of Leukocyte Adhesion and Migration in Phase 1 and 2 Clinical Studies for Immunological Disorders
35. Toll-Like Receptor Inhibitors in Phase 1 and 2 Clinical Studies for Immunological Disorders
36. IgE Inhibitors in Phase 1 and 2 Clinical Studies for Immunological Disorders
36 IgE Inhibitors in Phase 1 and 2 Clinical Studies for Immunological Disorders
37. Complement Inhibitors in Phase 1 and 2 Clinical Studies for Immunological Disorders
38. mAbs Targeting Apoptosis, Angiogenesis Inhibitors, and Other mAbs in Phase 1 and 2 Clinical Studies for Immunological Disorders
39. In vitro Studies and Clinical Trials about Monoclonal Antibodies Used in Infectiology
40. Immunotherapeutics for Neurological Disorders
41. Regulatory Considerations in the Development of Monoclonal Antibodies for Diagnosis and Therapy
42. Regulatory Review: Clinical to Market Transition
43. Monoclonal Antibody Nomenclature for Clinical Studies (USA)

Volume III: Approved Therapeutic Antibodies
Part VII: Approved Therapeutic Antibodies
44. Oligoclonal and Polyclonal Antibody Preparations
45. Adalimumab (Humira®)
46. Alemtuzumab (Lemtrada, MabCampath
47. Basiliximab (Simulect®) and Daclizumab (Zenapax®)
48. Belimumab (Benlysta®)
49. Brentuximab Vedotin (Adcetris®) for the Treatment of CD30-Positive Hematologic Malignancies
50. Canakinumab (ILARIS®)
51. Catumaxomab (Removab) –Trifunctional Antibodies: Combining Direct Tumor Cell Killing with Therapeutic
Vaccination
52. Cetuximab (Erbitux)
53. Denosumab (Prolia®)
54. Efalizumab (Raptiva)
55. Calicheamicin Conjugates: Gemtuzumab Ozogamicin (Mylotarg), Inotuzumab Ozogamicin
56. Golimumab (Simponi®)
57. Yttrium-90 Ibritumomab Tiuxetan (Zevalin®)
58. Infliximab (Remicade®)
59. Ipilimumab (Yervoy®)
60. Muromonab-CD3 (Orthoclone OKT®3)
61. Nimotuzumab: A Humanized Anti-EGFR Antibody
62. Obinutuzumab (Gazyva®), a Novel Glycoengineered Type II CD20 Antibody for the Treatment of Chronic
Lymphocytic Leukemia and Non-Hodgkin’s Lymphoma

Volume IV: Approved Therapeutic Antibodies and in vivo Diagnostics
63. Ofatumumab (Arzerra®): a Next-Generation Human Therapeutic CD20 Antibody with Potent Complement Dependent Cytotoxicity
64. Omalizumab (Xolair) – Anti-Immunoglobulin E Treatment in Allergic Diseases
65. Palivizumab (Synagis®)
66. Panitumumab (Vectibix®): A Treatment for Metastatic Colorectal Cancer
67. Pertuzumab (Perjeta®)
68. Ranibizumab (Lucentis): a New Anti-Angiogenic Treatment in Ophthalmology
69. Raxibacumab, Human Monoclonal Antibody against Anthrax Toxin
70. Rituximab (Rituxan®)
71. Tocilizumab (Actemra®)
72. Trastuzumab (Herceptin®) and Ado-Trastuzumab Emtansine (Kadcyla®): Treatments for HER2-Positive Breast Cancer
73. Ustekinumab (Stelara®)
74. Abciximab (Reopro®), Bevacizumab (Avastin®), Certolizumab Pegol (Cimzia®), Eculizumab (Soliris®),
Natalizumab (Tysabri®)
75. Itolizumab (Alzumab®), Mogamulizumab (Poteligeo®), and Tositumomab (Bexxar®)
76. Radiolabeled Antibodies for Diagnostic Imaging

Autores: Stefan Dubel, Janice M. Reichert
Editorial: Wiley.Blackwell
Edición: 2ª
Año: 2014
Volumen: 1, 2, 3 y 4
Páginas: 2333
ISBN: 978-3-527-32937-3
Idioma: Inglés

PASSWORD/CONTRASEÑA: www.rinconmedico.me

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