Metabolic Syndrome Underlying Mechanisms and Drug Therapies – Minghan Wang | Rincón Médico

Metabolic Syndrome Underlying Mechanisms and Drug Therapies – Minghan Wang


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Metabolic Syndrome Underlying Mechanisms and Drug Therapies
This book provides a comprehensive overview of the development of metabolic syndrome, the underlying mechanisms and therapeutic strategies for drug development. The authors examine the context of underlying molecular pathways and integrated physiology, then expanding the discussion to diseases associated with metabolic syndrome. The development of drug therapies for these diseases and complications is extensively covered. The book offers a comprehensive and in­depth view of energy metabolism, metabolic tissues and pathways, molecular mechanism­based drug discovery and clinical implications.

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CONTENTS:
Part One The Physiology of Metabolic Tissues Under Normal and Disease States
1. Gut as an Endocrine Organ: the Role of Nutrient Sensing in Energy Metabolism
2. Central Glucose Sensing and Control of Food Intake and Energy Homeostasis
3. Abnormalities in Insulin Secretion in Type 2 Diabetes Mellitus
4. Adipokine Production by Adipose Tissue: A Novel Target for Treating Metabolic Syndrome and its Sequelae
5. Hepatic Metabolic Dysfunctions in Type 2 Diabetes:Insulin Resistance and Impaired Glucose Production and Lipid
Synthesis
6. Energy Metabolism in Skeletal Muscle and its Link to Insulin Resistance
Part Two Metabolic Diseases and Current Therapies
7. Mechanisms and Complications of Metabolic Syndrome
8. Emerging Therapeutic Approaches for Dyslipidemias Associated with High LDL and Low HDL
9. Mechanism of Action of Niacin: Implications for Atherosclerosis and Drug Discovery
10. Current Antidiabetic Therapies and Mechanisms
Part Three Drug Targets for Antidiabetic Therapies
11. GLP­1 Biology, Signaling Mechanisms, Physiology, and Clinical Studies
12. Dipeptidyl Peptidase IV Inhibitors for Treatment of Diabetes
13. Sodium Glucose Cotransporter 2 Inhibitors
14. Fibroblast Growth Factor 21 as a Novel Metabolic Regulator
15. Sirtuins as Potential Drug Targets for Metabolic Diseases
16. 11b­Hydroxysteroid Dehydrogenase Type 1 as a Therapeutic Target for Type 2 Diabetes
17. Monoclonal Antibodies for the Treatment of Type 2 Diabetes: A Case Study with Glucagon Receptor Blockade
Part Four Lessons Learned and Future Outlook
18. Drug Development for Metabolic Diseases: Past, Present and Future
Autor: Minghan Wang
Editorial: W i l e y
Edición: 1ª
Año: 2011
Páginas: 510
ISBN­10: 0470343427
ISBN­13: 978­0470343425
Idioma: Inglés

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