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The Neutrophils

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The Neutrophils New Outlook for Old Cells 3rd Edition
This is a third edition of the monograph that was first published 12 years ago. At that time, interest in neutrophils witnessed a revival, due to new technological advances allowing a more detailed analysis of their biology. Since then, attention to the process did not subside but, on the contrary, has only been enhanced.

During the last seven years, since publication of the second edition of the book, the field of neutrophils research has made tremendous progress. Neutrophils remain a test ground for new hypoth-eses in signal transduction, reactive oxygen production, mechanisms of cell motility and adhesion. The results of these studies continue to have widespread implications for our understanding of many biological pro-cesses. Emerging understanding of the close link between innate and adaptive immunity put neutrophils into a prominent position in the ini-tiation and regulation of immune responses. New information also impli-cates pathologically activated neutrophils, and their precursors, in the regulation of the immune response in cancer.


Chapter 1: Molecular Regulation of Granulopoiesis
1.1. Introduction
1.2. Sequential Steps of PMN Development
1.3. Regulation of Steady State Granulopoiesis
1.4. Emergency Granulopoiesis
1.5. Conclusion

Chapter 2: The Neutrophil Respiratory Burst Oxidase
2.1. Introduction
2.2. NADPH Oxidase Components
2.3. Oxidase Protein Binding Interactions
2.4. Model of NADPH Oxidase Assembly
2.5. Oxidant Production

Chapter 3: Novel Neutrophil Receptors and Their Signal Transduction
3.1. Introduction
3.2. Siglecs
3.3. Triggering Receptor Expressed by Myeloid Cells (TREM)

Chapter 4: Mechanisms of Neutrophil Migration
4.1. Introduction
4.2. Historical Perspective on Leukocyte Adhesion and Emigration (1669-1955)
4.3. Molecular Adhesive Events Preceding Neutrophil Transendothelial Migration
4.4. Integrin Regulation of Neutrophil Transendothelial Migration
4.5. Paracellular Neutrophil Transendothelial Migration
4.6. Transcellular Neutrophil Transendothelial Migration
4.7. Endothelial Permeability Responses to Neutrophil Transendothelial Migration
4.8. The Role of Platelets in Neutrophil Transmigration
4.9. Concluding Remarks

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Chapter 5: Cytokine Production by Neutrophils
5.1. Introduction
5.2. General Features of Cytokine Production by Human Neutrophils
5.3. Production of Specific Cytokines by Neutrophils
5.4. Cross-Talk with Other Cells
5.5. Patterns of Cytokine Production in Human Neutrophils

Chapter 6: Neutrophils and Apoptosis

6.1. Introduction
6.2. Apoptosis
6.3. Neutrophil Lifespan Under Basal and Inflammatory Conditions
6.4. Signalling Pathways Controlling Neutrophil Apoptosis
6.5. Recognition and Clearance of Apoptotic Neutrophils
6.6. Neutrophil Apoptosis and the Resolution of Inflammation
6.7. Conclusions and Future Directions of Apoptosis Research

Chapter 7: Regulation of Neutrophil Functions by Long Chain Fatty Acids
7.1. Introduction
7.2. Fatty Acids
7.3. Metabolism of Arachidonic Acid and Other Fatty Acids
7.4. Biological Properties of AA
7.5. Effects of n-3 Fatty Acids, Eicosapentaenoic and Docosahexaenoic Acid on Neutrophils
7.6. Regulation of Neutrophil Functions by Metabolites of AA
7.7. Biological Properties of Resolvins and Protectins
7.8. Relationship Between Fatty Acid Structure and Biological Function
7.9. Cytokine-Induced Alteration in Neutrophil Responses to Polyunsaturated Fatty Acids
7.10. Neutrophil Priming Properties of Fatty Acids
7.11. Mechanisms of Fatty Acid-Induced Neutrophil Activation
7.12. Modulation of TNF Receptor Expression
7.13. Novel Polyunsaturated Fatty Acids
7.14. Summary

Chapter 8: S100 Calgranulins in Inflammation
8.1. S100s in Neutrophils
8.2. Calgranulin Structure
8.3. Disease Associations
8.4. Mechanisms of Secretion
8.5. Intracellular Functions
8.6. Extracellular Functions
8.7. Functions Learnt from Murine Models
8.8. Oxidant Scavenging by S100A8 and S100A9
8.9. Summary

Chapter 9: Neutrophils and Myeloid-Derived Suppressor Cells in Cancer
9.1. Neutrophils in Cancer; A Concept Revisited
9.2. Expansion of MDSC in Cancer
9.3. The Nature of PMN-MDSC in Cancer
9.4. Reactive Oxygen Species and PMN-MDSC

Chapter 10: Colony-Stimulating Factors for Prevention and Treatment of Neutropenia and Infectious Diseases
10.1. Characteristics of G-CSF, GM-CSF and their Receptors
10.2. Neutrophil and Monocyte Development, Deployment and Function
10.3. CSF Levels in Health and Disease
10.4. CSF and Chemotherapy-Induced Neutropenia
10.5. CSF and Management of Severe Chronic Neutropenia
10.6. CSF for the Treatment of Infectious Diseases
10.7. Summary Comments

Title: The Neutrophils New Outlook for Old Cells
Edition: 3rd Edition
Author: Dmitry Gabrilovich


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